Small-Molecule Triggers of Tadpole Metamorphosis
نویسندگان
چکیده
منابع مشابه
Small-molecule triggers of tadpole metamorphosis.
Small molecules that function as highly selective agonists and antagonists of cellular receptors comprise some of the most valuable therapeutic agents and molecular probes. A recent paper describes the design, synthesis, and evaluation of CO23, the first potent and specific agonist of thyroid hormone receptor-alpha (TRalpha), a member of the nuclear receptor (NR) superfamily of transcription fa...
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125I-labeled deoxyuridine (IdUrd) has been used to estimate the turnover of DNA in liver, tail, and hind limb during spontaneous and triiodothyronine-induced metamorphosis. It was found that the total amount of liver DNA remained constant and there was no significant loss of the label from the liver DNA, which would be expected if there was an increase in DNA turnover during metamorphosis. Also...
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The reorganization of cranial cartilages during tadpole metamorphosis is a set of complex processes. The fates of larval cartilage-forming cells (chondrocytes) and sources of adult chondrocytes are largely unknown. Individual larval cranial cartilages may either degenerate or remodel, while many adult cartilages appear to form de novo during metamorphosis. Determining the extent to which adult ...
متن کاملBiochemical studies on amphibian metamorphosis. III. Metabolism of nucleic acids and nucleotides in tadpole liver during thyroxine-induced metamorphosis.
Previous papers from this laboratory on the biochemical changes occurring during the thyroxine-induced metamorphosis of tadpoles have been concerned primarily with the biosynthesis of carbamyl phosphate synthetase. The acceleration of the synthesis of this enzyme in the presence of this hormone has been shown to be relatively specific and to precede morphological changes. It has been demonstrat...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2006
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb600398a